Šiba

Šiba is a village and municipality in Bardejov District in the Prešov Region of north-east Slovakia.

History

In historical records the village was first mentioned in 1427.

Geography

The municipality lies at an altitude of 400 metres and covers an area of 13.825 km². It has a population of about 570 people.

External links

Coordinates: 49°14′N 21°14′E / 49.233°N 21.233°E / 49.233; 21.233

IBA

IBA or iba may refer to:

Iba

IBA

AIF1

Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene.

Gene

The AIF1 gene is located within a segment of the major histocompatibility complex class III region. It has been shown that this gene is highly expressed in testis and spleen, but weakly expressed in brain, lung, and kidney. Among brain cells, the Iba1 gene was specifically expressed in microglia. Upon activation of microglia due to inflammation, expression of Iba1 is upregulated allowing the discrimination between surveiling and activated microglia.

Function

AIF1 is a protein that exists in the cytoplasm, and it is highly evolutionarily conserved. It is also possibly identical to three other proteins, Iba-1, MRF-1 (microglia response factor) and daintain. However complete functional profiles of all three proteins and how they overlap is unknown. IBA1 is a 17-kDa EF hand protein that is specifically expressed in macrophages / microglia and is upregulated during the activation of these cells. Iba1 expression is up-regulated in microglia following nerve injury, central nervous system ischemia, and several other brain diseases.

Paraná

Paraná or Parana may refer to:

Geology

Rivers

Places

Other

See also

Paraná (footballer)

Adhemir de Barros best known as Paraná (born in Cambará, Paraná, Brazil, March 21, 1942) was an association footballer. He played at São Bento, São Paulo, Londrina, and Brazil national football team, which had participated at 1966 FIFA World Cup, playing one match.

References

Paraná (state)

Paraná (Portuguese pronunciation: [paɾaˈna]) is one of the 26 states of Brazil, located in the south of the country, bordered on the north by São Paulo state, on the east by the Atlantic Ocean, on the south by Santa Catarina state and the Misiones Province of Argentina, and on the west by Mato Grosso do Sul and the republic of Paraguay, with the Paraná River as its western boundary line.

Cut by the Tropic of Capricorn, Paraná has what is left of the araucaria forest, one of the most important subtropical forests in the world. At the border with Argentina is the National Park of Iguaçu, considered by UNESCO as a World Heritage site. At only 40 km (25 mi) from there, at the border with Paraguay, the largest dam in the world was built, the Hidroelétrica de Itaipu (Itaipu Hydroelectric Dam).

History

Colonisation of the state by settlers started in the 16th century, but was mainly confined to the coasts. In the 1940s, the northern part of the state was settled as a result of the expansion of the São Paulo coffee industry. The south-eastern part of the state was settled as a result of migration from Rio Grande do Sul.